Neurogenesis in the adult hippocampus
The herpes simplex virus thymidine kinase (HSV-TK) has been used in studies in conjunction with antiviral drugs to inhibit adult neurogenesis.
The first evidence of adult mammalian neurogenesis in the cerebral cortex was presented by Joseph Altman in 1962, 119 followed by a demonstration of adult neurogenesis in the dentate gyrus of the hippocampus in 1963.
Although we often simply talk of neurogenesis in the hippocampus, precisely, neurogenesis occurs only in the dentate gyrus, not in other subregions; and, in an older nomenclature, the dentate gyrus is not even part of the hippocampus proper (but the hippocampal formation).
80 In recent years, scientists have provided evidence for the existence of neural stem cells with the potential to produce new neurons, particularly of a dopaminergic phenotype, in the adult mammalian brain.CNS Neurol Disord sex offenders online uk Drug Targets.On the precursor cell level, the cascade originates in a radial glia-like type 1 cell, presumably the highest ranking stem cell in this system.57 Allopregnanolone has been shown through reversing impairment of neurogenesis to reverse the cognitive deficits in a mouse model of Alzheimer's disease.This review deals with the description of this process and the restriction points at which regulation occurs."Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice".Granule cells are the excitatory principal neurons of the dentate gyrus.And aging can result in a decreased neuronal proliferation.17 18 Axolotls have contributed as a bridge organism between invertebrates and mammals, as the species has the regenerative capacity to undergo complete neurogenesis forming a wide range of neuronal populations not limited to a small niche, 19 yet the complexity and architecture is complex.The radial cells represent the largely quiescent compartment, and the control of quiescence is also under the control of gaba that comes from the local parvalbumin-expressing interneurons (basket cells) ( Song.2004 ; Schmidt-Hieber.In rodents, many of the newborn dentate gyrus neurons die shortly after they are born, 4 but a number of them become functionally integrated into the surrounding brain tissue.